IMPACT OF AGE-RELATED HORMONAL CHANGES ON PATHOGENETIC MACHANISMS OF GENITAL TUMORS IN MENOPAUSE

Abstract

The article provides information about a study investigating the impact of hormonal and metabolic changes during menopause on the mechanisms of development of benign and malignant tumors in the reproductive organs. A total of 306 women with various benign and malignant genital tumors in the postmenopausal period were examined. Their average age was 59.3 ± 0.4 years, and the duration of the menopausal period was 9.8 ± 0.4 years. All patients were conducted clinical, radiological, physical, morphological and laboratory examinations. It was found that, depending on the type of tumor, 32-70% of the women included in the study had various degrees of obesity. The average BMI value was 30.3 ± 0.4%, ranged from 17-61 kg/m2. Patients with endometrial hyperplasia and endometrial cancer had obesity of various degree, 63.1% and 70% respectively. Hormone studies revealed that women with benign and malignant tumors in the postmenopausal period exhibited hyperandrogenia, hyperprolactinemia, and hyperestrogenia due to increased estrone synthesis. Thus, age-related hormonal changes can be considered a risk factor for the development of genital tumors in the postmenopausal period.